2-Bromoanisole → HCID 178506687, compound

HRID 889681Notes

Reaction equation

HRID 889681 reaction equation
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][CH3:9].[Li:10]CCCC>CCCCCCC>[CH3:9][O:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[Li:10]

Participants

4

Reactant 2

HCID 113582-BromoanisoleHCID 178418339Butyllithium

Product 1

HCID 178506687HCID 178506687, compound

Reagents, catalysts & solvents 1

HCID 8900HeptaneSolvent

Procedure

To a solution of 2-bromoanisole (11.2 g, 60.08 mmol) in heptane (150 mL) was slowly added n-BuLi (1.6 M in hexenes, 36.7 mL). White precipitate formed. The slurry was stirred for 0.5 hrs and was filtered. The solid was washed with pentane and was dried under vacuum. The yield was 6.5 g (94%).

Workup

  1. customWhite precipitate
  2. customformed
  3. filtrationwas filtered
  4. washThe solid was washed with pentane
  5. customwas dried under vacuum

Sources & evidence

ORD record
ord-ec2f5590760e4e5ab661faeaf95ea4e4
Source dataset
uspto-grants-2012_08
Patent number
US08252955B2

Reaction notes

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