3-Amino-1-propanol → 3-(4-fluorobenzylamino)-1-propanol

HRID 889836Notes

Reaction equation

HRID 889836 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][OH:5].[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11]Cl)=[CH:9][CH:8]=1>>[F:6][C:7]1[CH:14]=[CH:13][C:10]([CH2:11][NH:1][CH2:2][CH2:3][CH2:4][OH:5])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 90863-Amino-1-propanolHCID 96024-Fluorobenzyl chloride

Product 1

HCID 45824023-(4-fluorobenzylamino)-1-propanolYield 64%

Procedure

In a similar manner to Reference Example 23, 3-amino-1-propanol (52.0 g) was reacted with 4-fluorobenzylchloride (10.0 g) to obtain 3-(4-fluorobenzylamino)-1-propanol (8.10 g, 64%).

Sources & evidence

ORD record
ord-2405315c68f54e1191ff65874a6cd444
Source dataset
uspto-grants-2006_02
Patent number
US06995153B2

Reaction notes

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