Hydrochloric Acid → HCID 86759931, compound

HRID 890369Notes

Reaction equation

HRID 890369 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][CH2:10][CH2:9][CH:8]2[NH2:13])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:15][OH:16]>>[C:1]1([C@@H:7]2[CH2:12][CH2:11][CH2:10][CH2:9][C@H:8]2[N:13]=[C:15]=[O:16])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 5449902-Phenylcyclohexan-1-amine

Product 1

HCID 86759931HCID 86759931, compound

Conditions

Temperature
110 °C

Procedure

To a solution of 2-phenylcyclohexylamine (2.28 mmol) in methanol was added HCl (4.0 M in dioxane, 0.57 mL). The solution was concentrated and treated with phosgene solution (20% in toluene, 16.0 mL). The reaction was heated at 110° C. overnight and concentrated in vacuo.

Workup

  1. concentrationThe solution was concentrated
  2. additiontreated with phosgene solution (20% in toluene, 16.0 mL)
  3. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-bfbe4890639d4b41a750273ac3274b6d
Source dataset
uspto-grants-2006_02
Patent number
US06995269B2

Reaction notes

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