反应详情

温度

70 °C

A mixture of 4-phenylcyclohexanone (28.7 mmol), hydroxylamine hydrochloride (36.0 mmol), and sodium acetate (60.95 mmol) in ethanol and water was heated at 70° C. overnight. Ethanol was removed, and the residue was dissolved in water and ethyl acetate. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried, and concentrated to give 1-(hydroxyimino)-4-phenylcyclohexane (97%).

1. customEthanol was removed
2. dissolutionthe residue was dissolved in water
3. extractionThe aqueous layer was extracted with ethyl acetate
4. washThe combined organic layers were washed with brine
5. customdried
6. concentrationconcentrated