Hydrochloric Acid → HCID 21935704, compound

HRID 890433Notes

Reaction equation

HRID 890433 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][CH:5]=1)=[O:3].[CH2:14]=O.[ClH:16].[CH3:17][NH:18][CH3:19].Cl>CCO>[ClH:16].[CH3:17][N:18]([CH3:14])[CH2:19][CH2:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:11])([F:12])[F:13])=[CH:6][CH:5]=1)=[O:3]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 712FormaldehydeHCID 10473Dimethylamine, hydrochlorideHCID 697311-(4-(Trifluoromethyl)phenyl)ethan-1-one

Product 1

HCID 21935704HCID 21935704, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-(Trifluoromethyl) acetophenone (4.97 g, 26.4 mmol), paraformaldehyde (1.586 g, 2 eq.), dimethylamine hydrochloride (3.23 g, 1.5 eq.) were mixed together in 7 ml of EtOH, treated with 0.08 ml of 37% HCl, and heated to reflux for 5 h. Cooling down to ambient temperature, filtration and washing with tiny amounts of cold EtOH delivered 4.59 g of the title compound as white crystals, mp. 128–142° C. (dec.).

Workup

  1. temperatureheated
  2. temperatureto reflux for 5 h
  3. washwashing with tiny amounts of cold EtOH

Sources & evidence

ORD record
ord-59f839cc33c845198423be89eef3b917
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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