Aluminium lithium hydride → HCID 21935866, compound

HRID 890483Notes

Reaction equation

HRID 890483 reaction equation
C[O:2][C:3](=O)[C:4]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:7]([C:14]2[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=2)=[N:6][CH:5]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[F:24][C:21]([F:22])([F:23])[O:20][C:17]1[CH:18]=[CH:19][C:14]([C:7]2[N:6]=[CH:5][C:4]([CH2:3][OH:2])=[C:9]([C:10]([F:13])([F:11])[F:12])[CH:8]=2)=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 86597783HCID 86597783, compound

Product 1

HCID 21935866HCID 21935866, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

In analogy to the procedure described in example 16 c], 6-(4-trifluoromethoxy-phenyl)-4-trifluoromethyl-nicotinic acid methyl ester was treated with lithium aluminium hydride in tetrahydrofuran under reflux conditions for 12 h to give the title compound as yellow oil.

Sources & evidence

ORD record
ord-466bc1b6325f41a48cc4c647572eff73
Source dataset
uspto-grants-2006_02
Patent number
US06995263B2

Reaction notes

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