反应详情

2-Cyclopropyl-acetimidic acid methyl ester hydrochloride (1 g, 7 mmol), 2,2-dimethyl-[1,3]dioxane-4,6-dione (963 mg, 7 mmol) and triethylamine (1.07 ml, 8 mmol) in chloroform (7 ml) were heated under reflux conditions for 14 h. The mixture was diluted with dichloromethane, washed neutral with brine/ice water 1/1 and the organic layer was dried over sodium sulfate. The solvent was removed under reduced pressure and the residue purified by flash chromatography (silica gel, heptane/AcOEt) to give 128 mg (0.6 mmol, 9%) of the title compound as yellow crystals.

1. washwashed neutral with brine/ice water 1/1
2. dry with materialthe organic layer was dried over sodium sulfate
3. customThe solvent was removed under reduced pressure
4. customthe residue purified by flash chromatography (silica gel, heptane/AcOEt)