Hydrochloric Acid → HCID 131725272, compound

HRID 890565Notes

Reaction equation

HRID 890565 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:19]=[C:20]([F:22])[CH:21]=1)[CH2:5][O:6][C:7]1[N:12]=[C:11]([N:13]2[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]2)[CH:10]=[CH:9][N:8]=1.[ClH:23].CCOCC>ClCCl>[ClH:23].[F:22][C:20]1[CH:19]=[C:4]([CH:3]=[C:2]([F:1])[CH:21]=1)[CH2:5][O:6][C:7]1[N:12]=[C:11]([N:13]2[CH2:14][CH2:15][NH:16][CH2:17][CH2:18]2)[CH:10]=[CH:9][N:8]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 9944361HCID 9944361, compound

Product 1

HCID 131725272HCID 131725272, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

2-(3,5-Difluoro-benzyloxy)-4-piperazin-1-yl-pyrimidine (1-A) (27.5 mg, 0.09 mmol) was dissolved in 1 mL of dichloromethane and treated with 1M hydrogen chloride in ether (89.8 μL, 0.09 mmol) and shaken for one minute. The reaction was then concentrated under a stream of nitrogen to give 30.8 mg of a yellow solid as the title compound (1-B).

Workup

  1. concentrationThe reaction was then concentrated under a stream of nitrogen

Sources & evidence

ORD record
ord-9470519576464d8fa191cc2e3d86f5fa
Source dataset
uspto-grants-2006_02
Patent number
US06995159B2

Reaction notes

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