Ammonium Hydroxide → HCID 23598856, compound

HRID 891006Notes

Reaction equation

HRID 891006 reaction equation
C([O:4][C@@H:5]1[C@@H:10]([O:11]C(=O)C)[C@H:9]([O:15]C(=O)C)[C@@H:8]([CH2:19][O:20]C(=O)C)[O:7][C@H:6]1[N:24]1[C:28]2=[N:29][CH:30]=[CH:31][CH:32]=[C:27]2[C:26]([C:33]2[C:34](=[O:49])[N:35]([CH3:48])[C:36](=[O:47])[C:37]=2[C:38]2[C:46]3[C:41](=[N:42][CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)=[CH:25]1)(=O)C.[OH-].[NH4+]>CO>[CH3:48][N:35]1[C:36](=[O:47])[C:37]([C:38]2[C:46]3[C:41](=[N:42][CH:43]=[CH:44][CH:45]=3)[NH:40][CH:39]=2)=[C:33]([C:26]2[C:27]3[C:28](=[N:29][CH:30]=[CH:31][CH:32]=3)[N:24]([C@@H:6]3[O:7][C@H:8]([CH2:19][OH:20])[C@@H:9]([OH:15])[C@H:10]([OH:11])[C@H:5]3[OH:4])[CH:25]=2)[C:34]1=[O:49]

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 23598862HCID 23598862, compound

Product 1

HCID 23598856HCID 23598856, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of the compound of Example 14b (0.054 mmol), dissolved in 14 ml of methanol, there is added 28% aqueous ammonium hydroxide solution (10 ml). The reaction mixture is stirred for 26 hours at ambient temperature. After evaporating off the solvents, the residue is purified by chromatography on silica gel (ethyl acetate/methanol: 9/1), allowing the expected product to be isolated.

Workup

  1. customAfter evaporating off the solvents
  2. customthe residue is purified by chromatography on silica gel (ethyl acetate/methanol: 9/1)
  3. customto be isolated

Sources & evidence

ORD record
ord-35aec8580ee54936b824b658cc88bd20
Source dataset
uspto-grants-2006_02
Patent number
US07001906B2

Reaction notes

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