Hydrochloric Acid → 2-[3-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethanol

HRID 891068Notes

Reaction equation

HRID 891068 reaction equation
[C:1]1([CH:7]([C:11](=O)[CH3:12])[C:8](=O)[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:14]([C:16]1[CH:17]=[C:18]([CH2:22][CH2:23][OH:24])[CH:19]=[CH:20][CH:21]=1)[NH2:15].Cl>>[CH3:12][C:11]1[C:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)=[C:8]([CH3:9])[N:14]([C:16]2[CH:17]=[C:18]([CH2:22][CH2:23][OH:24])[CH:19]=[CH:20][CH:21]=2)[N:15]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 2334023-Phenyl-2,4-pentanedioneHCID 222446052-(3-Hydrazinophenyl)ethanol

Product 1

HCID 222445462-[3-(3,5-Dimethyl-4-phenyl-1H-pyrazol-1-yl)phenyl]ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 1 from 3-phenyl-2,4-pentanedione and 2-(3-hydrazinophenyl)ethanol (WO 94/07896) hydrochloride: MS (ESI) m/z 293 [M+H]+, 1H-NMR (CDCl3) δ 7.44-7.22 (9H, m), 3.87 (2H, t, J=6.0 Hz), 2.67 (2H, t, J=6.0 Hz), 2.33 (3H, s), 2.15 (3H, s).

Sources & evidence

ORD record
ord-22bdb1f5e6ff4af8b6b32b9a98f60d2a
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

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