Phenylboronic Acid → 2-{4-[5-Methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol

HRID 891119Notes

Reaction equation

HRID 891119 reaction equation
Br[C:2]1[C:3]([C:17]([F:20])([F:19])[F:18])=[N:4][N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[C:6]=1[CH3:7].[C:21]1(B(O)O)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>>[CH3:7][C:6]1[N:5]([C:8]2[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[CH:10][CH:9]=2)[N:4]=[C:3]([C:17]([F:20])([F:19])[F:18])[C:2]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 222446842-{4-[4-Bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol

Product 1

HCID 222446382-{4-[5-Methyl-4-phenyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol

Procedure

The title compound was prepared according to the procedure described in step 1 of Example 12 from 2-{4-[4-bromo-5-methyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}ethanol (step 2) and phenylboronic acid: MS (ESI) m/z 346 [M+H]+, 1H-NMR (CDCl3) δ 7.44-7.32 (9H, m), 3.89-3.83 (2H, m), 2.94-2.89 (2H, m), 2.33 (3H, s), 2:32 (3H, s)

Sources & evidence

ORD record
ord-0d1de417f4e346d3b168ffaed88449bf
Source dataset
uspto-grants-2006_02
Patent number
US07001917B2

Reaction notes

Loading…