Hydrochloric Acid → (5-Methoxypyridazin-3-yl)methanol

Temperature

0 °C

5-Methoxy-pyridazine-3-carboxylic acid ethyl ester (8.1 g, 44.5 mmol) was dissolved in ethanol (105 ml) under argon. The reaction mixture was cooled to 0° C. and treated with NaBH4 (3.5 g, 89 mmol). After 10 minutes, the reaction mixture was warmed to room temperature, stirred for 1 hour and treated successively with 2N HCl and saturated sodium bicarbonate to adjust the pH at 8. The solvent was removed in vacuo and the residue was stirred with MeOH (100 ml). The suspension was filtered and the filtrate was concentrated. The residue was chromatographed over silica gel (CH2Cl2—MeOH 19:1) to provide (5-methoxy-pyridazin-3-yl)-methanol (5.2 g, 83%) as a light brown solid, MS: m/e=140 (M+).

1. temperaturethe reaction mixture was warmed to room temperature
2. customThe solvent was removed in vacuo
3. stirringthe residue was stirred with MeOH (100 ml)
4. filtrationThe suspension was filtered
5. concentrationthe filtrate was concentrated
6. customThe residue was chromatographed over silica gel (CH2Cl2—MeOH 19:1)

ORD record

ord-f6aeae6adc7f4e68a6cb71a2ab701636

Source dataset

uspto-grants-2006_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07005432B2