HCID 10182569, compound → HCID 9869935, compound

HRID 892006Notes

Reaction equation

HRID 892006 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:27]=[CH:28][C:29]=1[Cl:30])[O:5][CH:6]1[CH2:11][CH2:10][N:9]([CH2:12][CH:13]([OH:26])[CH2:14][O:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[NH:22]C(=O)C)[CH2:8][CH2:7]1>Cl>[ClH:1].[ClH:1].[NH2:22][C:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][CH2:14][CH:13]([OH:26])[CH2:12][N:9]1[CH2:8][CH2:7][CH:6]([O:5][C:4]2[CH:27]=[CH:28][C:29]([Cl:30])=[C:2]([Cl:1])[CH:3]=2)[CH2:11][CH2:10]1

Participants

3

Reactant 1

HCID 10182569HCID 10182569, compound

Product 1

HCID 9869935HCID 9869935, compoundYield 165.3%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

N-(2-{3-[4-(3,4-dichlorophenoxy)-1-piperidinyl]-2-hydroxypropoxy}phenyl)acetamide (1.418 g, 3.13 mmol, prepared by analogy to Example 1) was dissolved in 50 ml HCl (35%/aq, puriss) and refluxed overnight. The product precipitated and was filtered and dried to give 0.835 g (65%) of the title compound.

Workup

  1. temperaturerefluxed overnight
  2. customThe product precipitated
  3. filtrationwas filtered
  4. customdried

Sources & evidence

ORD record
ord-8d7436b7149146d7b650137949113a05
Source dataset
uspto-grants-2006_02
Patent number
US07005439B2

Reaction notes

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