反应详情

温度

5 °C

To a solution of benzoic acid 3-[2-(5-ethyl-pyridin-2-yl)-ethoxy]-phenyl ester (493 mg, 1.42 mmol, example 70) in 1:1 THF/CH3OH (5 mL) is added 10N NaOH soln. (0.5 mL) and water (50 μL). The reaction mixture is stirred for 15 min then cooled to 5° C., adjusted to pH 7 with 2N HCl soln. and diluted with EtOAc. The organic layer is washed sequentially with brine, sat NaHCO3 soln. then dried over MgSO4 and concentrated. The residue is purified by several triturations with hexane to give the title compound as a crystalline solid. MS (ESI) 244 (M+H)+.

1. washThe organic layer is washed sequentially with brine
2. dry with materialthen dried over MgSO4
3. concentrationconcentrated
4. customThe residue is purified by several triturations with hexane