Trifluoroacetic acid → HCID 178524166, compound

HRID 892337Notes

Reaction equation

HRID 892337 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[NH2:11])[C:5]([OH:7])=[O:6].[C:12](O)([C:14]([F:17])([F:16])[F:15])=O>Cl>[F:15][C:14]([F:17])([F:16])[C:12]1[NH:11][C:10]2[CH:9]=[CH:8][C:4]([C:5]([OH:7])=[O:6])=[CH:3][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 692633,4-Diaminobenzoic acid

Product 1

HCID 178524166HCID 178524166, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
0 °C

Procedure

50 g (0.329 mol) of 3,4-diaminobenzoic acid, dissolved in 300 ml of 4N HCl, are heated under reflux with 40.5 g (0.355 mol) of TFA for 5 hours. The solution is then cooled to 0° C., and the precipitated product is filtered off with suction, washed with water and dried at 40° C. in vacuo.

Workup

  1. temperatureare heated
  2. filtrationthe precipitated product is filtered off with suction
  3. washwashed with water
  4. customdried at 40° C. in vacuo

Sources & evidence

ORD record
ord-49b0477375c94e169e6a6c58042f7c87
Source dataset
uspto-grants-1992_06
Patent number
USRE033948

Reaction notes

Loading…