Propylamine → HCID 135537129, compound

HRID 892436Notes

Reaction equation

HRID 892436 reaction equation
Cl[C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[N:3]=1.[CH2:19]([NH2:22])[CH2:20][CH3:21]>C(O)C>[CH2:19]([NH:22][C:2]1[N:3]=[C:4]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[O:15][CH2:16][CH2:17][CH3:18])[NH:5][C:6](=[O:8])[CH:7]=1)[CH2:20][CH3:21]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 178458304HCID 178458304, compound

Product 1

HCID 135537129HCID 135537129, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

4-Chloro-6-hydroxy-2-(2-propoxyphenyl)pyrimidine (0.66 g), n-propylamine (1.8 g) and ethanol (20 ml) was heated at 90° C. in a pressure vessel for 16 hours. The cooled reaction mixture was evaporated under reduced pressure to lo yield an oil which solidified on washing with water. The residue was recrystallised from isopropanol: water to yield the title compound, 0.56 g, m.p. 172°-3° C.

Workup

  1. customThe cooled reaction mixture
  2. customwas evaporated under reduced pressure
  3. customto lo yield an oil which
  4. washon washing with water
  5. customThe residue was recrystallised from isopropanol

Sources & evidence

ORD record
ord-e0be2acdc011471a9a345b38f6d44286
Source dataset
uspto-grants-1992_06
Patent number
US05118686

Reaction notes

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