HCID 19895770, compound → HCID 19895762, compound

HRID 892467Notes

Reaction equation

HRID 892467 reaction equation
[CH2:1]([N:4]([CH:18]1[CH2:27][CH2:26][C:25]2[C:20](=[CH:21][CH:22]=[CH:23][C:24]=2[OH:28])[CH2:19]1)[CH2:5][CH2:6][N:7]1[C:15](=O)[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:8]1=O)[CH2:2][CH3:3].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH2:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH2:15][N:7]1[CH2:6][CH2:5][N:4]([CH2:1][CH2:2][CH3:3])[CH:18]1[CH2:27][CH2:26][C:25]2[C:24]([OH:28])=[CH:23][CH:22]=[CH:21][C:20]=2[CH2:19]1

Participants

4

Reactant 2

HCID 19895770HCID 19895770, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 19895762HCID 19895762, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The product of Example 13 was reduced with LAH in dry THF and, after purification, the isolated compound was characterized by its HCl.salt NMR, (CD3OD) δ7.7 (m, 4H), 6.9 (m, 1H), 6.6 (m, 2H), 1.0 (t, 3H).

Workup

  1. customafter purification

Sources & evidence

ORD record
ord-76c1cb9457da4529824b74fee485dd75
Source dataset
uspto-grants-1992_06
Patent number
US05118704

Reaction notes

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