反应详情

温度

-30 °C

A solution of 2-oxopyrrolidine (5.00 g) in THF (60 ml) was cooled to -50° C., and a 1.55 M n-BuLi/THF solution (38 ml) was dropwise added thereto. After 0.5 hour's stirring at -30° C., succinic anhydride (6.00 g) was added dropwise, followed by stirring at a temperature of -30°--20° C. for 0.5 hour. The reaction mixture was poured into ice water and adjusted to pH 4 with 1N hydrochloric acid, and extracted with n-butanol. The organic layer was washed with saturated brine and concentrated to give 9.42 g of 4-oxo-4-(2-oxo-1-pyrrolidinyl)butyric acid.

1. stirringby stirring at a temperature of -30°--20° C. for 0.5 hour
2. extractionextracted with n-butanol
3. washThe organic layer was washed with saturated brine
4. concentrationconcentrated