Hydrochloric Acid → HCID 19894083, compound

HRID 892806Notes

Reaction equation

HRID 892806 reaction equation
Cl.C(O[C:7]([N:9](C)[C:10]1[CH:11]=[C:12]([CH:21]=[CH:22][CH:23]=1)[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14])=O)(C)(C)C>C(Cl)Cl>[CH3:7][NH:9][C:10]1[CH:11]=[C:12]([CH:21]=[CH:22][CH:23]=1)[C:13]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19894101HCID 19894101, compound

Product 1

HCID 19894083HCID 19894083, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Hydrochloric acid in dioxanes (4M, 7 mL) was added to a solution of N-tert-butoxycarbonyl-N-methyl-3-aminobenzophenone (2.2 g, 7.4 mmol) in methylene chloride (5 mL). The mixture was stirred at room temperature for 1 hour and then concentrated. The residue was partitioned between chloroform and saturated sodium bicarbonate solution and the organic layer was washed with saturated sodium chloride and dried over sodium sulfate. The solvent was removed in vacuo to yield the desired product.

Workup

  1. concentrationconcentrated
  2. customThe residue was partitioned between chloroform and saturated sodium bicarbonate solution
  3. washthe organic layer was washed with saturated sodium chloride
  4. dry with materialdried over sodium sulfate
  5. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-f2a2e07f460b4431b08a0cede742f2c2
Source dataset
uspto-grants-1992_06
Patent number
US05120751

Reaction notes

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