Thiazolidinedione → HCID 14459866, compound

HRID 892815Notes

Reaction equation

HRID 892815 reaction equation
[CH3:1][N:2]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12]Br)=[CH:8][CH:7]=1)(=[O:5])=[O:4].[S:22]1[CH2:26][C:25](=[O:27])[NH:24][C:23]1=[O:28].C(OCC)(=O)C>CCCCCC>[CH3:1][N:2]([CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[S:3]([C:6]1[CH:11]=[CH:10][C:9]([CH2:12][CH:26]2[S:22][C:23](=[O:28])[NH:24][C:25]2=[O:27])=[CH:8][CH:7]=1)(=[O:5])=[O:4]

Participants

5

Reactant 3

HCID 5437ThiazolidinedioneHCID 8857Ethyl AcetateHCID 14459965HCID 14459965, compound

Product 1

HCID 14459866HCID 14459866, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

By the method of Example 1, N-methyl-N-(2-phenylethyl)-4-(bromomethyl)benzenesulfonamide (10.6 mmol, 3.9 g) and thiazolidine-2,4-dione (11.7 mmol 1.4 g,), using 1:2 ethyl acetate:hexane as eluant, were converted to 3.3 g purified title product as a gum.

Workup

  1. custompurified title product as a gum

Sources & evidence

ORD record
ord-a82a6f9175c544fa9c886f87f00370c9
Source dataset
uspto-grants-1992_06
Patent number
US05120754

Reaction notes

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