p-Toluenesulfonic acid → HCID 15177083, compound

HRID 892928Notes

Reaction equation

HRID 892928 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH2:8][OH:9])[CH:7]=1.[O:13]1[CH:18]=[CH:17][CH2:16][CH2:15][CH2:14]1.CC1C=CC(S(O)(=O)=O)=CC=1.C(=O)([O-])[O-].[Na+].[Na+]>ClCCl>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH2:8][O:9][CH:14]2[CH2:15][CH2:16][CH2:17][CH2:18][O:13]2)[CH:7]=1

Participants

6

Reactant 4

HCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 10340Sodium CarbonateHCID 5560665-Chloro-2-nitrobenzyl alcohol

Product 1

HCID 15177083HCID 15177083, compoundYield 99.6%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 25 parts of 5-chloro-2-nitrobenzenemethanol, 13.3 parts of dihydro-2H-pyran, 300 parts of dichloromethane and 0.28 parts of 4-methylbenzenesulfonic acid was stirred for 2 hours at reflux temperature. After cooling, the reaction mixture was neutralized with sodium carbonate and stirred for 10 min. The whole was filtered and the filtrate was evaporated. The residue was co-evaporated with methylbenzene and then purified by columns chromatography (silica gel; CHCl3). The eluent of the desired fraction was evaporated and the residue was co-evaporated with methylbenzene, yielding 36 parts (99.6%) of 2-[(5-chloro-2-nitrophenyl)methoxy]tetrahydro-2H-pyran (interm. 1).

Workup

  1. temperatureat reflux temperature
  2. temperatureAfter cooling
  3. stirringstirred for 10 min
  4. filtrationThe whole was filtered
  5. customthe filtrate was evaporated
  6. custompurified by columns chromatography (silica gel; CHCl3)
  7. customThe eluent of the desired fraction was evaporated

Sources & evidence

ORD record
ord-8a2fe224545e4c89a5208e1e1723258d
Source dataset
uspto-grants-1992_06
Patent number
US05120845

Reaction notes

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