Tetrahydrofuran → 3-[3-chloro-5-(5-fluoro-2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

HRID 89294Notes

Reaction equation

HRID 89294 reaction equation
[C:34]([Li:35])([CH3:36])([CH3:37])[CH3:38].[CH2:29]1[O:30][CH2:31][CH2:32][CH2:33]1.[CH3:50][CH2:51][O:52][C:53]([CH3:54])=[O:55].[Cl:1][c:2]1[c:3](-[c:13]2[c:14]([CH3:28])[n:15][c:16]3[n:17]2[n:18][c:19]([CH3:27])[cH:20][c:21]3[CH:22]([CH2:23][CH3:24])[CH2:25][CH3:26])[s:4][c:5](-[c:7]2[n:8]([CH3:12])[n:9][cH:10][n:11]2)[cH:6]1.[F:39][NH:40][S:41]([c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1)(=[O:48])=[O:49]>>[Cl:1][c:2]1[c:3](-[c:13]2[c:14]([CH3:28])[n:15][c:16]3[n:17]2[n:18][c:19]([CH3:27])[cH:20][c:21]3[CH:22]([CH2:23][CH3:24])[CH2:25][CH3:26])[s:4][c:5](-[c:7]2[n:8]([CH3:12])[n:9][c:10]([F:39])[n:11]2)[cH:6]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 15373214N-FluorobenzenesulfonamideHCID 579330443-[3-chloro-5-(2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazineHCID 178418306HCID 178418306, compound

Product 1

HCID 579329143-[3-chloro-5-(5-fluoro-2-methyl-2H-[1,2,4]triazol-3-yl)-thiophen-2-yl]-8-(1-ethyl-propyl)-2,6-dimethyl-imidazo[1,2-b]pyridazine

Sources & evidence

ORD record
ord-dccc537b9cf748ac931950a9f436adf5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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