Hydrochloric Acid → HCID 19894618, compound

HRID 893017Notes

Reaction equation

HRID 893017 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20]3[C:25]([NH:26][CH2:27][CH3:28])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:15]2)[CH:5]=[C:6]([CH3:9])[C:7]=1[OH:8].CCOCC.[ClH:34]>C(OCC)(=O)C>[ClH:34].[ClH:34].[CH3:9][C:6]1[CH:5]=[C:4]([CH2:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][N:17]([C:20]3[C:25]([NH:26][CH2:27][CH3:28])=[CH:24][CH:23]=[CH:22][N:21]=3)[CH2:16][CH2:15]2)[CH:3]=[C:2]([CH3:1])[C:7]=1[OH:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 19894531HCID 19894531, compound

Product 1

HCID 19894618HCID 19894618, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

2-[4-(4-(3,5-Dimethyl-4-hydroxyphenyl)butyl)piperazin-1-yl]-N-ethyl-3-pyridineamine (EXAMPLE 44) Is dissolved in ethyl acetate and treated in excess with ether which was saturated with hydrogen chloride gas. The salt is filtered and dried under reduced pressure to give the title compound.

Workup

  1. filtrationThe salt is filtered
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-b100c3200075480f9f158195c2da1a18
Source dataset
uspto-grants-1992_06
Patent number
US05120843

Reaction notes

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