Formaldehyde → HCID 11776435, compound

HRID 893143Notes

Reaction equation

HRID 893143 reaction equation
[Cl-].[Li+].C(OP([CH:11]([CH2:17][C:18]1[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1)[C:12]([O:14][CH2:15][CH3:16])=[O:13])(OCC)=O)C.[CH2:28]1CCN2C(=NCCC2)CC1.C=O>C1COCC1>[C:18]1([CH2:17][C:11](=[CH2:28])[C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:27]2[C:22](=[CH:23][CH:24]=[CH:25][CH:26]=2)[CH:21]=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 270093NSC112269HCID 433294Lithium Chloride

Product 1

HCID 11776435HCID 11776435, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent3×

Procedure

1.92 g of lithium chloride was suspended in 50 ml of dry THF, and 15 g of ethyl 2-diethylphosphono-3-(1-naphthyl)propionate was dropwise added thereto. Then, 16 ml of a 50% dry THF solution of DBU was dropwise added thereto, and 2.01 g of paraformaldehyde suspended in dry THF was added thereto. The mixture was stirred at room temperature for 3 hours, and the insolubles were removed by filtration and washed with a small amount of diethyl ether. The washing solution and and the filtrate were put together, and the solvent was distilled off. The resulting syrup was dissolved in 180 ml of diethyl ether. The diethyl ether layer was washed sequentially with a 10% citric acid aqueous solution, with water and with a saturated sodium chloride aqueous solution and dried over anhydride sodium sulfate. The solvent was distilled off, and the syrup thereby obtained was purified by silica gel column chromatography (n-hexane/diethyl ether=20/1) to obtain 6.48 g of ethyl 2-(1-naphthyl)methyl-2-propenoate as colorless oily substance.

Workup

  1. additionwas added
  2. customthe insolubles were removed by filtration
  3. washwashed with a small amount of diethyl ether
  4. distillationthe solvent was distilled off
  5. dissolutionThe resulting syrup was dissolved in 180 ml of diethyl ether
  6. washThe diethyl ether layer was washed sequentially with a 10% citric acid aqueous solution, with water and with a saturated sodium chloride aqueous solution
  7. dry with materialdried over anhydride sodium sulfate
  8. distillationThe solvent was distilled off
  9. customthe syrup thereby obtained
  10. customwas purified by silica gel column chromatography (n-hexane/diethyl ether=20/1)

Sources & evidence

ORD record
ord-aff5988ea6514822b42aa288d9f05e84
Source dataset
uspto-grants-1992_06
Patent number
US05122523

Reaction notes

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