反应详情

1.4 g of anhydrous potassium carbonate and 1.0 g of 1-chloro-2-butene were added to 1.6 g of 3-aminobenzotrifluoride in 30 ml of dimethylformamide, followed by stirring at 70°-90° C. for 2 hours. Potassium carbonate was then removed by filtration, and 100 ml of an aqueous saturated sodium chloride solution were added and extraction was then carried out with toluene. After drying over anhydrous sodium sulfate, the solvent was distilled off, and silica gel chromatography was then done to obtain 1.4 g of the desired compound.

1. customPotassium carbonate was then removed by filtration, and 100 ml of an aqueous saturated sodium chloride solution
2. additionwere added
3. extractionextraction
4. dry with materialAfter drying over anhydrous sodium sulfate
5. distillationthe solvent was distilled off