Potassium Carbonate → N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

HRID 893187Notes

Reaction equation

HRID 893187 reaction equation
[Cl:1][CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[C:3](Cl)=[O:4].[CH2:13]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[CH:14]=[CH:15][CH3:16].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH2:13]([N:17]([C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[C:20]([CH:25]([CH3:27])[CH3:26])[CH:19]=1)[C:3](=[O:4])[CH:2]([Cl:1])[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([F:12])[CH:7]=1)[CH:14]=[CH:15][CH3:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 198914902-Chloro-2-(3-fluorophenyl)acetyl chlorideHCID 54500563HCID 54500563, compound

Product 1

HCID 54355070N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)-2-chloro-2-(3-fluorophenyl)acetamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.6 g of 2-chloro-2-(3-fluorophenyl)acetyl chloride were gradually added dropwise to 2.2 g of N-(2-butenyl)-N-(4-chloro-3-isopropylphenyl)amine and 2.0 g of anhydrous potassium carbonate in 40 ml of N,N-dimethylformamide with stirring at 20°-30° C. After the stirring was additionally continued for 20 minutes, potassium carbonate was removed by filtration, and extraction was then carried out with toluene. After drying over anhydrous sodium sulfate, the reaction solution was concentrated by means of an evaporator to quantitatively obtain the desired oily product.

Workup

  1. custompotassium carbonate was removed by filtration, and extraction
  2. dry with materialAfter drying over anhydrous sodium sulfate
  3. concentrationthe reaction solution was concentrated by means of an evaporator
  4. customto quantitatively obtain the desired oily product

Sources & evidence

ORD record
ord-211ba34586764a49a4b4afa93feb9e93
Source dataset
uspto-grants-1992_06
Patent number
US05123954

Reaction notes

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