Potassium Carbonate → HCID 54500563, compound

HRID 893188Notes

Reaction equation

HRID 893188 reaction equation
C(=O)([O-])[O-].[K+].[K+].Cl[CH2:8][CH:9]=[CH:10][CH3:11].[Cl:12][C:13]1[CH:19]=[CH:18][C:16]([NH2:17])=[CH:15][C:14]=1[CH:20]([CH3:22])[CH3:21]>CN(C)C=O>[CH2:8]([NH:17][C:16]1[CH:18]=[CH:19][C:13]([Cl:12])=[C:14]([CH:20]([CH3:22])[CH3:21])[CH:15]=1)[CH:9]=[CH:10][CH3:11]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 11589Crotyl chlorideHCID 198914954-Chloro-3-isopropylaniline

Product 1

HCID 54500563HCID 54500563, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

2.8 g of anhydrous potassium carbonate and 2.0 g of -chloro-2-butene were added to 3.2 g of 4-chloro-3-isopropylaniline in 15 ml of N,N-dimethylformamide, followed by stirring at 70°-90° C. for 1 hour. After potassium carbonate was removed by filtration, 100 ml of water were added, and extraction was then carried out with toluene. After drying over anhydrous sodium sulfate, the reaction solution was concentrated by means of an evaporator, and silica gel chromatography was then done to obtain 1.5 g of the desired compound.

Workup

  1. customAfter potassium carbonate was removed by filtration, 100 ml of water
  2. additionwere added
  3. extractionextraction
  4. dry with materialAfter drying over anhydrous sodium sulfate
  5. concentrationthe reaction solution was concentrated by means of an evaporator, and silica gel chromatography

Sources & evidence

ORD record
ord-57918c3994a8439ebf7f53a9cf1c35f4
Source dataset
uspto-grants-1992_06
Patent number
US05123954

Reaction notes

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