Dicyclohexylcarbodiimide → HCID 19096838, compound

HRID 893229Notes

Reaction equation

HRID 893229 reaction equation
[CH3:1][O:2][CH:3]([C:10]([O-:12])=O)[C:4]([O:6][CH2:7][CH2:8][CH3:9])=[O:5].[Cl:13][C:14]1[CH:15]=[C:16]([CH:18]=[C:19]([Cl:21])[CH:20]=1)[NH2:17].C1(N=C=NC2CCCCC2)CCCCC1>>[Cl:13][C:14]1[CH:15]=[C:16]([NH:17][C:10](=[O:12])[CH:3]([O:2][CH3:1])[C:4]([O:6][CH2:7][CH2:8][CH3:9])=[O:5])[CH:18]=[C:19]([Cl:21])[CH:20]=1

Participants

4

Reactant 3

HCID 10868DicyclohexylcarbodiimideHCID 122813,5-DichloroanilineHCID 85670801HCID 85670801, compound

Product 1

HCID 19096838HCID 19096838, compoundYield 28.6%

Procedure

Mono-n-propyl methoxymalonate (13.07 grams, 0.07 mole), prepared in Part B, 3,5-dichloroaniline (12.02 grams, 0.07 mole) and 1,3-dicyclohexylcarbodiimide (15.31 grams, 0.07 mole) were reacted in a manner similar to that described in Example LVII to give 7.22 grams (0.02 mole) of n-propyl 3-[(3,5-dichlorophenyl)amino]-2-methoxy-3-oxopropanoate having a melting point of 89° C.-93° C. An analytical sample recrystallized from hexane had a melting point of 89° C.-92° C.

Workup

  1. customwere reacted in a manner similar to

Sources & evidence

ORD record
ord-ccc7c5488c45483caf0bd19096462525
Source dataset
uspto-grants-1992_06
Patent number
US05123951

Reaction notes

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