Hydrochloric Acid → HCID 15728797, compound

HRID 893262Notes

Reaction equation

HRID 893262 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9]3=[C:10]([C:12](=[O:15])C(=O)[N:8]3[CH:7]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH2:6][CH2:5]2)[CH:11]=1.[OH-:22].[Na+].OO.Cl>O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([C:12]([OH:22])=[O:15])[CH:11]=1)[NH:8][CH:7]([C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)[CH2:6][CH2:5]2

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 19892016HCID 19892016, compound

Product 1

HCID 15728797HCID 15728797, compoundYield 96.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a solution of 8-chloro-5,6-dihydro-4-phenyl-4H-pyrrolo-[3,2,1-ij]quinoline-1,2-dione (3.4 g) and sodium hydroxide (2 g) in water (100 ml) was added 35% aqueous hydrogen peroxide solution (5 ml) and stirred at room temperature for an hour. The reaction mixture was acidified slightly by adding concentrated hydrochloric acid, the resulting precipitate was collected by filtration, washed and dried to give the title compound (3.17 g, 96.7%) as yellow crystals. This crystals was recrystallized from ethanol to pale yellow needles, mp 199°-200 ° C.

Workup

  1. filtrationthe resulting precipitate was collected by filtration
  2. washwashed
  3. customdried

Sources & evidence

ORD record
ord-7101be7001e7461697560143b706ac13
Source dataset
uspto-grants-1992_06
Patent number
US05124325

Reaction notes

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