Hydrochloric Acid → HCID 22314793, compound

HRID 893397Notes

Reaction equation

HRID 893397 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[C:15]1(=O)[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1.[C-:22]#[N:23].[K+]>O>[CH2:1]([N:8]1[CH2:13][CH2:12][N:11]([C:15]2([C:22]#[N:23])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]2)[CH2:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 7967CyclohexanoneHCID 9032Potassium CyanideHCID 759941-Benzylpiperazine

Product 1

HCID 22314793HCID 22314793, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
0 °C

Procedure

1-Benzylpiperazine (Aldrich) (6.12 g) was dissolved in 10 ml deionized water and cooled to 0° C. Concentrated hydrochloric acid (3.6 ml) was added to adjust the pH to 5. After warming to room temperature, 3.6 ml cyclohexanone was added, followed by potassium cyanide (2.4 g) in 6 ml deionized water. The solution slowly became cloudy. After 18 hours, the solid was filtered. The solid was dissolved in chloroform, dried over Na2SO4, filtered and the solvent was removed in vacuo to yield pure 1-benzyl-4-(1-cyanocyclohexyl) piperazine.

Workup

  1. temperatureAfter warming to room temperature
  2. filtrationthe solid was filtered
  3. dissolutionThe solid was dissolved in chloroform
  4. dry with materialdried over Na2SO4
  5. filtrationfiltered
  6. customthe solvent was removed in vacuo

Sources & evidence

ORD record
ord-5fab700551774aa9bf29e5716b69d519
Source dataset
uspto-grants-1992_06
Patent number
US05124457

Reaction notes

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