Lithium Hydroxide → HCID 15341824, compound

HRID 893466Notes

Reaction equation

HRID 893466 reaction equation
[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH2:35][CH3:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([O:18]CC)=[O:17].[OH-].[Li+]>CO>[CH3:1][O:2][C:3]1[C:4]([CH2:34][CH2:35][CH3:36])=[C:5]([CH:27]=[CH:28][C:29]=1[C:30]([NH:32][CH3:33])=[O:31])[O:6][CH2:7][CH2:8][CH2:9][O:10][C:11]1[C:12]([CH2:24][CH2:25][CH3:26])=[C:13]([CH:21]=[CH:22][CH:23]=1)[O:14][CH2:15][C:16]([OH:18])=[O:17]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341823HCID 15341823, compound

Product 1

HCID 15341824HCID 15341824, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 45 (70 mg, 0.1395 mmol) and 279 μl of 1 M lithium hydroxide was added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature overnight. The solvent was removed under vacuum and 2.0 ml of water was added, and the solution was acidified with 10% hydrochloric acid and then extracted three times with ethyl acetate. The extracts were combined and the solvent was removed under vacuum to give the product.

Workup

  1. customThe solvent was removed under vacuum and 2.0 ml of water
  2. additionwas added
  3. extractionextracted three times with ethyl acetate
  4. customthe solvent was removed under vacuum
  5. customto give the product

Sources & evidence

ORD record
ord-f4f0c6a5cb2b471fb8e3beae5e585612
Source dataset
uspto-grants-1992_06
Patent number
US05124350

Reaction notes

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