Lithium Hydroxide → HCID 15341834, compound

HRID 893474Notes

Reaction equation

HRID 893474 reaction equation
[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([O:20]CC)=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3].[OH-].[Li+]>CO>[NH2:1][C:2]([C:4]1[CH:30]=[CH:29][C:7]([O:8][CH2:9][CH2:10][CH2:11][O:12][C:13]2[C:14]([CH2:26][CH2:27][CH3:28])=[C:15]([CH:23]=[CH:24][CH:25]=2)[O:16][CH2:17][C:18]([OH:20])=[O:19])=[C:6]([CH2:31][CH:32]=[CH2:33])[C:5]=1[O:34][CH3:35])=[O:3]

Participants

4

Reactant 2

HCID 3939Lithium HydroxideHCID 15341833HCID 15341833, compound

Product 1

HCID 15341834HCID 15341834, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The compound of Example 55 (100 mg, 0.195 mmol) and 390 μl of 1 M lithium hydroxide (0.3896 mmol) were added to 2.0 ml of methanol, and the reaction mixture was stirred at room temperature for 4 hours. The solvent was removed under vacuum, 5.0 ml of water was added to the residue, and the mixture was acidified with 10% hydrochloric acid. The mixture was filtered, and the white solid which was recovered was dried in a 40° C. oven overnight to give the product.

Workup

  1. customThe solvent was removed under vacuum, 5.0 ml of water
  2. additionwas added to the residue
  3. filtrationThe mixture was filtered
  4. customthe white solid which was recovered
  5. customwas dried in a 40° C. oven overnight
  6. customto give the product

Sources & evidence

ORD record
ord-d903b85a75c84494a26076e615d488ce
Source dataset
uspto-grants-1992_06
Patent number
US05124350

Reaction notes

Loading…