Tetrahydrofuran → HCID 15764665, compound

Temperature

50 °C

To a stirred mixture of 20.0 g (0.0681 mole) of 2-(2-chloro-4-fluoro-5-nitrophenyl)-1,3-dithiane in 150 mL of acetic acid was added 75 mL of tetrahydrofuran. Iron powder (15.8 g, 0.269 mole) was added portionwise. Upon complete addition, the reaction mixture was heated to about 50° C. for approximately 30 minutes. The reaction mixture was cooled in an ice bath and was diluted with diethyl ether. The resultant mixture was filtered through a pad of Celite® filter aid. Water was added to the filtrate, and the organic phase was removed. An aqueous, sodium bicarbonate solution was added to the organic phase with vigorous stirring until the mixture was slightly basic. The aqueous phase was allowed to separate from the organic phase and was removed. The aqueous phase was extracted with diethyl ether, and the extracts were added to the organic phase. This organic solution was dried over anhydrous magnesium sulfate and was filtered. The filtrate was evaporated under reduced pressure to yield 13.5 g of 2-(5-amino-2-chloro-4-fluorophenyl)-1,3-dithiane as a solid, m.p. 112°-115° C.

1. additionUpon complete addition
2. temperatureThe reaction mixture was cooled in an ice bath
3. filtrationThe resultant mixture was filtered through a pad of Celite®
4. filtrationfilter aid
5. additionWater was added to the filtrate
6. customthe organic phase was removed
7. additionAn aqueous, sodium bicarbonate solution was added to the organic phase
8. customto separate from the organic phase
9. customwas removed
10. extractionThe aqueous phase was extracted with diethyl ether
11. additionthe extracts were added to the organic phase
12. dry with materialThis organic solution was dried over anhydrous magnesium sulfate
13. filtrationwas filtered
14. customThe filtrate was evaporated under reduced pressure

ORD record

ord-7b2b02098e1444e2952655b95a532e75

Source dataset

uspto-grants-1992_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05125958