Ethyl bromoacetate → HCID 19890432, compound

HRID 893535Notes

Reaction equation

HRID 893535 reaction equation
[C:1]1([P:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:20][CH2:21][C:22]([O:24][CH2:25][CH3:26])=[O:23]>C1C=CC=CC=1>[C:22]([O:24][CH2:25][CH3:26])(=[O:23])[CH3:21].[Br-:20].[C:14]1([PH+:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 2

HCID 7748Ethyl bromoacetateHCID 11776Triphenylphosphine

Product 1

HCID 19890432HCID 19890432, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

In a nitrogen atmosphere, 31.47 g (120 mM) of triphenylphosphine was added to 60 ml of benzene, and 23.38 g (140 mM) of ethyl bromoacetate was added under cooling with ice. After 1 hour of stirring at room temperature, the resultant precipitate salt was taken out by filtration and washed with benzene to obtain 48.90 g of ethyl acetate-triphenyl phosphonium bromide. Yield: 95%.

Workup

  1. additionwas added
  2. temperatureunder cooling with ice
  3. filtrationthe resultant precipitate salt was taken out by filtration
  4. washwashed with benzene

Sources & evidence

ORD record
ord-0fcfc6e794f743438cfe8628797ceb23
Source dataset
uspto-grants-1992_06
Patent number
US05126071

Reaction notes

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