反应详情

0.48 g of 3-trifluoromethyl-1-heptanol was dissolved in 0.79 g of pyridine, and the solution was cooled with ice, followed by addition of 0.5 g of p-toluenesulfonyl chloride, stirring for 2 hours under cooling with ice and stirring for 2 hours at room temperature. After the reaction, the product was acidified with 2N-hydrochloric acid and extracted with methylene chloride. The resultant methylene chloride solution was washed with water and dried with magnesium sulfate, and the solvent was distilled off, whereby 3-trifluoromethylheptyl p-toluenesulfonate was obtained in an amount of 0.82 g (yield: 92%) and showed: [α]D23 +0.5, [α]D23 +2.2 (c 2, methylene chloride).

1. temperaturethe solution was cooled with ice
2. temperatureunder cooling with ice
3. stirringstirring for 2 hours at room temperature
4. customAfter the reaction
5. extractionextracted with methylene chloride
6. washThe resultant methylene chloride solution was washed with water
7. dry with materialdried with magnesium sulfate
8. distillationthe solvent was distilled off