Tetrahydrofuran → HCID 21622760, compound

HRID 893638Notes

Reaction equation

HRID 893638 reaction equation
O1C=CC([NH:6][CH2:7][C:8]#[N:9])=C1.C(N(CC)CC)C.Cl.[C:18](Cl)(=O)[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1.[CH2:27]1[CH2:31][O:30][CH2:29][CH2:28]1>>[CH2:18]([NH:9][CH:8]([C:28]1[CH:27]=[CH:31][O:30][CH:29]=1)[C:7]#[N:6])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)HCID 19891029HCID 19891029, compound

Product 1

HCID 21622760HCID 21622760, compound

Procedure

2.3 g of the α-(3-furyl)aminoacetonitrile and 4.1 g of triethylamine were dissolved in 100 ml of THF. Then 3.6 g of nicotinic acid chloride hydrochloride was added thereto under ice-cooling. The obtained mixture was stirred for one hour and then at room temperature for six hours. After filtering the solid matter thus formed, the solvent was distilled off. The obtained oily substance was purified by column chromatography to thereby give 2.7 g of α-(nicotinylamino)-(3-furyl) acetonitrile in the form of crystals.

Workup

  1. temperatureunder ice-cooling
  2. waitat room temperature for six hours
  3. filtrationAfter filtering the solid matter
  4. customthus formed
  5. distillationthe solvent was distilled off
  6. customThe obtained oily substance was purified by column chromatography

Sources & evidence

ORD record
ord-ae23b76e4041466480f0c83279121a1d
Source dataset
uspto-grants-1992_06
Patent number
US05126362

Reaction notes

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