Hydroxyamine hydrochloride → HCID 73656502, compound

HRID 893639Notes

Reaction equation

HRID 893639 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][CH2:7][C:8]#[N:9].[ClH:10].[NH2:11][OH:12]>CO>[ClH:10].[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[NH:6][CH2:7][C:8](=[N:11][OH:12])[NH2:9]

Participants

4

Reactant 2

HCID 443297Hydroxyamine hydrochlorideHCID 18381777HCID 18381777, compound

Product 1

HCID 73656502HCID 73656502, compoundYield 90.8%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5.6 g of the α-(2-thienyl)aminoacetonitrile thus obtained was dissolved in 30 ml of methanol and 2.8 g of hydroxylamine hydrochloride was added thereto in a water bath. After stirring for a while, the mixture began to crystallize while showing slight heat generation. The mixture was stirred at room temperature for several hours thereafter. After the completion of the reaction, the reaction mixture was concentrated and the solvent was distilled off. After recrystallizing from ethanol, 7.6 g of the aimed α-(2-thienyl)aminoacetamidoxime hydrochloride was obtained.

Workup

  1. customto crystallize
  2. stirringThe mixture was stirred at room temperature for several hours
  3. customAfter the completion of the reaction
  4. concentrationthe reaction mixture was concentrated
  5. distillationthe solvent was distilled off
  6. customAfter recrystallizing from ethanol

Sources & evidence

ORD record
ord-be0bbf2af4d046f2b5ea10dc2f883119
Source dataset
uspto-grants-1992_06
Patent number
US05126362

Reaction notes

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