Hydrochloric Acid → HCID 67915971, compound

HRID 893867Notes

Reaction equation

HRID 893867 reaction equation
[CH:1]1([NH:7][C:8]([C:10]2(C(OC(C)(C)C)=O)[S:22][C:13]34[CH:21]=[CH:20][CH:19]=[CH:18][C:14]3=[N:15][CH2:16][CH2:17][CH:12]4[CH2:11]2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:30]>C(OCC)(=O)C>[ClH:30].[CH:1]1([NH:7][C:8]([CH:10]2[S:22][C:13]34[CH:21]=[CH:20][CH:19]=[CH:18][C:14]3=[N:15][CH2:16][CH2:17][CH:12]4[CH2:11]2)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19891252N-cyclohexyl-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-carboamide

Product 1

HCID 67915971HCID 67915971, compoundYield 82%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Conditions

Temperature
50 °C

Procedure

g of N-cyclohexyl-2-tert-butoxycarbonyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-carboamide was added to 30 ml of ethyl acetate. A mixture of 5N hydrochloric acid and 13.3 ml of ethyl acetate was further added thereto and stirred for 2 hours at 50° C. to form a precipitate. The precipitate was separated by filtration and washed with 30 ml of ether to obtain 6.37 g of N-cyclohexyl-1,2,3,4-tetrahydro-benzo[b]thieno[2,3-c]pyridine-carboamide.hydrochloride (yield 82%).

Workup

  1. additionwas further added
  2. customto form a precipitate
  3. customThe precipitate was separated by filtration
  4. washwashed with 30 ml of ether

Sources & evidence

ORD record
ord-cde09b9f5321408985838c162c4bc700
Source dataset
uspto-grants-1992_06
Patent number
US05126448

Reaction notes

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