反应详情

Heat a mixture of 800 mg. of the nitrile of Example 2, Step F, 293 mg. of sodium azide and 265 mg. of ammonium chloride in 25 ml. of dimethylformamide at 130°-135° C. for 6 hours. Dilute the mixture with water and excess sodium carbonate. Extract with ethyl acetate. Acidify the aqueous phase and separate and precipitate by filtration to obtain the title product.

1. temperatureHeat
2. additiona mixture of 800 mg
3. extractionExtract with ethyl acetate
4. customseparate
5. filtrationprecipitate by filtration