2-Bromo-1,2-diphenylethan-1-one → HCID 20575031, compound

HRID 894269Notes

Reaction equation

HRID 894269 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:9].[Br:10][CH:11]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]>CC(C)=O>[BrH:10].[C:20]1([CH:11]2[S:9][C:2]3=[N:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:1]3[C:12]2([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[OH:13])[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

Participants

4

Reactant 2

HCID 1026302-Bromo-1,2-diphenylethan-1-oneHCID 53727341,3-Diazocane-2-thione

Product 1

HCID 20575031HCID 20575031, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent2×

Procedure

A 2.16 g. portion of hexahydro-1,3-diazocine-2(1H)-thione is dissolved in 800 ml. of hot acetone. The solution is clarified and then stirred as 4.2 g. of 2-bromo-2-phenylacetophenone in 50 ml. of acetone is added. The solution is stirred at room temperature for 7 hours, then the solid is collected, washed with 200 ml. of acetone and dried in vacuo at 60° C., giving 5.1 g. of the desired product, m.p. 211°-213° C. (dec.).

Workup

  1. stirringThe solution is stirred at room temperature for 7 hours
  2. customthe solid is collected
  3. washwashed with 200 ml
  4. dry with materialof acetone and dried in vacuo at 60° C.
  5. customgiving 5.1 g

Sources & evidence

ORD record
ord-a01b9037c169497c9e3f08616aa6bff9
Source dataset
uspto-grants-1981_08
Patent number
US04283334

Reaction notes

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