2-Bromopropiophenone → HCID 20575036, compound

HRID 894271Notes

Reaction equation

HRID 894271 reaction equation
[NH:1]1[CH2:8][CH2:7][CH2:6][CH2:5][CH2:4][NH:3][C:2]1=[S:9].[Br:10][CH:11]([CH3:20])[C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13]>CC(C)=O>[BrH:10].[CH3:20][CH:11]1[S:9][C:2]2=[N:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][N:1]2[C:12]1([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[OH:13]

Participants

4

Reactant 2

HCID 164522-BromopropiophenoneHCID 53727341,3-Diazocane-2-thione

Product 1

HCID 20575036HCID 20575036, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1.44 g. of hexahydro-1,3-diazocine-2(1H)-thione and 500 ml. of acetone is heated to produce solution. A 2.13 g. portion of 2-bromopropiophenone is added and the mixture is allowed to stand overnight. The solid is collected, washed with acetone and dried, giving 2.53 g. of the desired product, m.p. 191°-193° C. (dec.).

Workup

  1. additionA mixture of 1.44 g
  2. customto produce solution
  3. customThe solid is collected
  4. washwashed with acetone
  5. customdried
  6. customgiving 2.53 g

Sources & evidence

ORD record
ord-c3640c80029f48e6aec9d66022422c86
Source dataset
uspto-grants-1981_08
Patent number
US04283334

Reaction notes

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