Potassium Carbonate → HCID 12884239, compound

HRID 894399Notes

Reaction equation

HRID 894399 reaction equation
[CH2:1]([N:5]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6](=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1I)[CH2:2][CH2:3][CH3:4].[Cl:20][C:21]1[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[C:22]=1[NH2:23].C(=O)([O-])[O-].[K+].[K+]>C1(C)C(C)=CC=CC=1.[Cu]>[CH2:1]([N:5]([CH2:16][CH2:17][CH2:18][CH3:19])[C:6](=[O:15])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[NH:23][C:22]1[C:21]([Cl:20])=[CH:27][CH:26]=[CH:25][C:24]=1[Cl:28])[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 3

HCID 11430Potassium CarbonateHCID 118462,6-DichloroanilineHCID 12884233HCID 12884233, compound

Product 1

HCID 12884239HCID 12884239, compoundYield 81.1%

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 7237O-XyleneSolvent

Procedure

A mixture of 3.5 g (0.0095 mole) of N,N-di-n-butyl-o-iodophenylacetamide, 1.70 g (0.0105 mole) of 2,6-dichloroaniline, 1.46 g (0.0104 mole) of anhydrous potassium carbonate, 1.0 g of copper powder and 1.0 g of cuprous iodide was reacted in 53 ml of xylene for 45 hours. After completion of the reaction, the post treatment was carried out in the same manner as in Example 12 to obtain 3.14 g of N,N-di-n-butyl-o-(2,6-dichloroanilino)phenylacetamide in the form of a colorless needle having a melting point of 66° to 68° C. (after recrystallization from methanol).

Workup

  1. customAfter completion of the reaction

Sources & evidence

ORD record
ord-82d9b60777e94cd4aabbf08b56cc11e4
Source dataset
uspto-grants-1981_08
Patent number
US04283532

Reaction notes

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