Hydrochloric Acid → HCID 20574340, compound

HRID 894514Notes

Reaction equation

HRID 894514 reaction equation
[CH2:1]([N:4]1[CH2:8][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6]([OH:15])[C:5]1=[O:16])[CH:2]=[CH2:3].[CH3:17][N:18]([CH3:22])[CH2:19][CH2:20]Cl.Cl>C(OCC)(=O)C>[CH2:1]([N:4]1[CH2:8][C:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[C:6]([O:15][CH2:20][CH2:19][N:18]([CH3:22])[CH3:17])[C:5]1=[O:16])[CH:2]=[CH2:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79012-Chloro-N,N-dimethylethylamineHCID 20574349HCID 20574349, compound

Product 1

HCID 20574340HCID 20574340, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1, 30.6 g. 1-allyl-3-hydroxy-4-phenyl-3-pyrrolin-2-one are reacted with 23.0 g. β-dimethylaminoethyl chloride. The base obtained is reacted with gaseous hydrogen chloride in ethyl acetate. There is obtained 15.0 g. (45.5% of theory) 1-allyl-3-(β-dimethylaminoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride: m.p. 115°-117° C., after recrystallization from methyl ethyl ketone.

Workup

  1. customThe base obtained
  2. customThere is obtained 15.0 g
  3. custom(45.5% of theory) 1-allyl-3-(β-dimethylaminoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride: m.p. 115°-117° C., after recrystallization from methyl ethyl ketone

Sources & evidence

ORD record
ord-e508ed14fc0841278a763c9177af2140
Source dataset
uspto-grants-1981_08
Patent number
US04284632

Reaction notes

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