Hydrochloric Acid → HCID 20574338, compound

HRID 894515Notes

Reaction equation

HRID 894515 reaction equation
C(N1CC(C2C=CC=CC=2)=C(O)C1=O)C.N1(CCCl)CCCCC1.Cl.Cl.[CH2:27]([N:29]1[CH2:33][C:32]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[C:31]([O:40][CH2:41][CH2:42][N:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[C:30]1=[O:49])[CH3:28]>C(OCC)(=O)C>[CH2:27]([N:29]1[CH2:33][C:32]([C:34]2[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=2)=[C:31]([O:40][CH2:41][CH2:42][N:43]2[CH2:48][CH2:47][CH2:46][CH2:45][CH2:44]2)[C:30]1=[O:49])[CH3:28]

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 748271-(2-Chloroethyl)piperidineHCID 20574337HCID 20574337, compoundHCID 20574348HCID 20574348, compound

Product 1

HCID 20574338HCID 20574338, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

In a manner analogous to that described in Example 1, 30.5 g. 1-ethyl-3-hydroxy-4-phenyl-3-pyrrolin-2-one is reacted with 21.5 g. β-piperidinoethyl chloride. The base obtained is converted into the crystalline hydrochloride in ethyl acetate by means of gaseous hydrogen chloride. There is obtained 22.5 g. (42% of theory) 1-ethyl-3-(β-piperidinoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride; m.p. 120° C., (decomp.), after recrystallization from methyl ethyl ketone.

Workup

  1. customThe base obtained
  2. customThere is obtained 22.5 g
  3. customm.p. 120° C., (decomp.), after recrystallization from methyl ethyl ketone

Sources & evidence

ORD record
ord-c1951d1eea184685925eec5395c0b83f
Source dataset
uspto-grants-1981_08
Patent number
US04284632

Reaction notes

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