Hydrochloric Acid → HCID 20574353, compound

HRID 894516Notes

Reaction equation

HRID 894516 reaction equation
C(N1CC(C2C=CC=CC=2)=C(O)C1=O)C1OC=CC=1.CN(C)CCCl.Cl.Cl.[CH2:28]([N:34]1[CH2:38][C:37]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[C:36]([O:45][CH2:46][CH2:47][N:48]([CH3:50])[CH3:49])[C:35]1=[O:51])[C:29]1[O:33][CH:32]=[CH:31][CH:30]=1>C(OC(C)C)(C)C>[CH2:28]([N:34]1[CH2:38][C:37]([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)=[C:36]([O:45][CH2:46][CH2:47][N:48]([CH3:49])[CH3:50])[C:35]1=[O:51])[C:29]1[O:33][CH:32]=[CH:31][CH:30]=1

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 79012-Chloro-N,N-dimethylethylamineHCID 20574350HCID 20574350, compoundHCID 20574352HCID 20574352, compound

Product 1

HCID 20574353HCID 20574353, compound

Reagents, catalysts & solvents 1

HCID 7914Diisopropyl EtherSolvent

Procedure

25.5 g. 1-furfuryl-3-hydroxy-4-phenyl-3-pyrrolin-2-one is reacted with 20.0 g. β-dimethylaminoethyl chloride in a manner analogous to that described in Example 1. The base obtained is converted into the crystalline hydrochloride in diisopropyl ether by means of gaseous hydrogen chloride. There is obtained 7.5 g. (21% of theory) 1-furfuryl-3-(β-dimethylaminoethoxy)-4-phenyl-3-pyrrolin-2-one hydrochloride; m.p. 145°-148° C., after recrystallization from methyl ethyl ketone.

Workup

  1. customThe base obtained
  2. customThere is obtained 7.5 g
  3. customm.p. 145°-148° C., after recrystallization from methyl ethyl ketone

Sources & evidence

ORD record
ord-c56212922f5a4bd0a7a060bad45a46d7
Source dataset
uspto-grants-1981_08
Patent number
US04284632

Reaction notes

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