Imidazole → 1-Cyclooctylmethylimidazole

HRID 894523Notes

Reaction equation

HRID 894523 reaction equation
[CH3:1]Br.[CH2:3]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1.[NH:11]1[CH:15]=[CH:14][N:13]=[CH:12]1.[Na]>C(O)C>[CH:3]1([CH2:1][N:11]2[CH:15]=[CH:14][N:13]=[CH:12]2)[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][CH2:4]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 5360545SodiumHCID 20574510Cyclooctane methyl bromide

Product 1

HCID 205502381-Cyclooctylmethylimidazole

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Cyclooctane methyl bromide (5.5 g, 0.027 mole) was added dropwise to a refluxing solution of imidazole (2.0 g, 0.03 mole) in a solution of sodium (0.7 g, 0.03 mole) in absolute ethanol (50 ml). After addition the mixture was refluxed for a further 15 hours.

Workup

  1. additionAfter addition the mixture
  2. temperaturewas refluxed for a further 15 hours

Sources & evidence

ORD record
ord-86565ee5294d480d8d58018a4e38c497
Source dataset
uspto-grants-1981_08
Patent number
US04284641

Reaction notes

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