Imidazole → 1-Cycloheptyl-1H-imidazole

HRID 894534Notes

Reaction equation

HRID 894534 reaction equation
[CH:1]1(Br)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH:9]1[CH:13]=[CH:12][N:11]=[CH:10]1.C(=O)(O)[O-].[Na+]>CO>[CH:1]1([N:9]2[CH:13]=[CH:12][N:11]=[CH:10]2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 795ImidazoleHCID 16992BromocycloheptaneHCID 516892Sodium Bicarbonate

Product 1

HCID 201484671-Cycloheptyl-1H-imidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Cycloheptyl bromide (10.0 g, 0.0565 mole) was added dropwise to a refluxing mixture of imidazole (385 g, 0.0565 mole) and sodium bicarbonate (4.75 g, 0.0565 mole) im methanol (100 ml). After addition was complete the mixture was heated under reflux for a further 24 hours.

Workup

  1. additionAfter addition
  2. temperaturewas heated
  3. temperatureunder reflux for a further 24 hours

Sources & evidence

ORD record
ord-844f90349c9c45a5ae1510e432be5493
Source dataset
uspto-grants-1981_08
Patent number
US04284641

Reaction notes

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