Dimethyl Sulfate → HCID 20572385, compound

HRID 894924Notes

Reaction equation

HRID 894924 reaction equation
[F:1][C:2]([F:13])([F:12])[CH2:3][NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1.[C:14](=O)(O)[O-].[Na+].S(OC)(OC)(=O)=O>>[CH3:14][N:4]([CH2:3][C:2]([F:12])([F:13])[F:1])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH3:11])[CH:6]=1

Participants

4

Reactant 3

HCID 6497Dimethyl SulfateHCID 516892Sodium BicarbonateHCID 20572383HCID 20572383, compound

Product 1

HCID 20572385HCID 20572385, compound

Procedure

The same method as in Example 2 is carried out using 56.7 parts of N-(2,2,2-trifluoroethyl)-m-toluidine, 53 parts of sodium bicarbonate and 75 parts of dimethyl sulphate. 52.8 parts, i.e. a yield equal to 86.7% of the theoretical yield, of N-methyl N-(2,2,2-trifluoroethyl)-m-toluidine are obtained.

Sources & evidence

ORD record
ord-663f9ac7afe34269afccae55159f719e
Source dataset
uspto-grants-1981_08
Patent number
US04285696

Reaction notes

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