Chlorosuccinimide → HCID 10286369, compound

HRID 895217Notes

Reaction equation

HRID 895217 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([OH:8])[CH:5]=[C:4]([F:9])[C:3]=1[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[CH:16]=[C:15]([OH:20])[CH:14]=[CH:13]2.C1C(=O)N([Cl:28])C(=O)C1>C1COCC1>[Cl:28][C:16]1[C:17]2[C:12](=[CH:11][C:10]([C:3]3[C:2]([F:1])=[CH:7][C:6]([OH:8])=[CH:5][C:4]=3[F:9])=[CH:19][CH:18]=2)[CH:13]=[CH:14][C:15]=1[OH:20]

Participants

4

Reactant 2

HCID 31398ChlorosuccinimideHCID 10214708HCID 10214708, compound

Product 1

HCID 10286369HCID 10286369, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared by reacting 6-(2,6-difluoro-4-hydroxyphenyl)-2-naphthol (510 mg, 1.86 mmol) and NCS (301 mg, 2.25 mmol) in THF (30 mL) according to Method C to yield 440 mg (77%) of yellowish solid: mp 213-214° C.;

Sources & evidence

ORD record
ord-74afddeff0e74bf3ab2374d80f8f36ac
Source dataset
uspto-grants-2005_07
Patent number
US06914074B2

Reaction notes

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