Hydrochloric Acid → HCID 22386141, compound

HRID 895264Notes

Reaction equation

HRID 895264 reaction equation
[ClH:1].C([O:6][C:7]1[CH:46]=[CH:45][C:10]([C:11]([NH:13][C@H:14]2[C@H:20]([O:21][C:22](=[O:37])[C:23]3[CH:28]=[CH:27][C:26]([C:29](=[O:36])[C:30]4[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=4)=[CH:25][CH:24]=3)[CH2:19][CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15]2)=[O:12])=[CH:9][CH:8]=1)(C)(C)C>C(OCC)(=O)C>[ClH:1].[OH:6][C:7]1[CH:46]=[CH:45][C:10]([C:11]([NH:13][CH:14]2[CH:20]([O:21][C:22](=[O:37])[C:23]3[CH:28]=[CH:27][C:26]([C:29](=[O:36])[C:30]4[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=4)=[CH:25][CH:24]=3)[CH2:19][CH2:18][CH2:17][NH:16][CH2:15]2)=[O:12])=[CH:9][CH:8]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86754065HCID 86754065, compound

Product 1

HCID 22386141HCID 22386141, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

3.0 ml of 5N HCl in ethyl acetate were added at room temperature while stirring to 922 mg of the azepine prepared in Example 19 in 4.0 ml of ethyl acetate. The reaction mixture was stirred at room temperature overnight and the precipitate was filtered off, washed three times with 2 ml of ethyl acetate and dried at 50° C./25 mbar for 16 hours yielding 0.70 g of 3-(4-hydroxy-benzoylamino)-4-(4-benzoyl-benzoyloxy)-hexahydroazepine hydrochloride.

Workup

  1. filtrationthe precipitate was filtered off
  2. washwashed three times with 2 ml of ethyl acetate
  3. customdried at 50° C./25 mbar for 16 hours

Sources & evidence

ORD record
ord-1a86e81bcf994bd4aa876b5a709a8802
Source dataset
uspto-grants-2005_07
Patent number
US06914140B1

Reaction notes

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